Drug interactions
Eltrombopag + Sacubitril-valsartan
Severity: Minor
Eltrombopag and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1, which could modestly raise valsartan exposure; the legacy note incorrectly states a decrease. Clinical significance is likely small, but increased angiotensin receptor blocker effects such as hypotension are theoretically possible.
What this interaction means in plain words
Eltrombopag and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of valsartan by eltrombopag.
What to do
No empirical dose change is needed. Monitor blood pressure and renal function when starting eltrombopag.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Eltrombopag and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits OATP1B1, which could modestly raise valsartan exposure; the legacy note incorrectly states a decrease. Clinical significance is likely small, but increased angiotensin receptor blocker effects such as hypotension are theoretically possible.
How serious is the interaction between Eltrombopag and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood pressure and renal function when starting eltrombopag.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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