Drug interactions
Eltrombopag + Tolmetin
Severity: Minor
Eltrombopag and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 in vitro and could theoretically raise exposure to UGT-metabolized drugs such as tolmetin. The clinical significance is unclear and no meaningful effect has been established.
What this interaction means in plain words
Eltrombopag and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Tolmetin belongs to Musculoskeletal.
Why it happens
Possible in vitro inhibition of UGT enzymes by eltrombopag.
What to do
No routine action is needed; be aware of possible increased NSAID adverse effects if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Tolmetin?
MediHelp rates the interaction as minor. Eltrombopag and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 in vitro and could theoretically raise exposure to UGT-metabolized drugs such as tolmetin. The clinical significance is unclear and no meaningful effect has been established.
How serious is the interaction between Eltrombopag and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of possible increased NSAID adverse effects if symptoms develop.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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