Drug interactions
Eltrombopag + Valsartan
Severity: Minor
Eltrombopag and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 in vitro, which could raise valsartan exposure since valsartan is an OATP1B1 substrate. The clinical effect has not been shown and is likely small.
What this interaction means in plain words
Eltrombopag and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Valsartan belongs to Cardiovascular.
Why it happens
Potential inhibition of hepatic OATP1B1 uptake of valsartan by eltrombopag.
What to do
No routine adjustment; monitor blood pressure and watch for hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Valsartan?
MediHelp rates the interaction as minor. Eltrombopag and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits OATP1B1 in vitro, which could raise valsartan exposure since valsartan is an OATP1B1 substrate. The clinical effect has not been shown and is likely small.
How serious is the interaction between Eltrombopag and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor blood pressure and watch for hypotension.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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