Drug interactions
Eluxadoline + Fentanyl
Severity: Moderate
Eluxadoline and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS, and opioids such as fentanyl cause constipation. Together they increase the risk of severe constipation and related complications such as ileus or pancreatitis-like presentations.
What this interaction means in plain words
Eluxadoline and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor effects slowing gastrointestinal motility.
What to do
Avoid combining where possible; if constipation develops, stop eluxadoline and evaluate the patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Fentanyl?
MediHelp rates the interaction as moderate. Eluxadoline and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS, and opioids such as fentanyl cause constipation. Together they increase the risk of severe constipation and related complications such as ileus or pancreatitis-like presentations.
How serious is the interaction between Eluxadoline and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if constipation develops, stop eluxadoline and evaluate the patient.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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