Drug interactions
Eluxadoline + Glibenclamide
Severity: Moderate
Eluxadoline and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide inhibits OATP1B1, which can raise eluxadoline exposure. Increased eluxadoline levels may cause more adverse effects, such as constipation, pancreatitis and sphincter of Oddi spasm.
What this interaction means in plain words
Eluxadoline and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Glibenclamide belongs to Endocrine.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake reduces eluxadoline clearance.
What to do
Use the reduced eluxadoline dose of 75 mg twice daily recommended with OATP1B1 inhibitors. Monitor for abdominal pain and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Glibenclamide?
MediHelp rates the interaction as moderate. Eluxadoline and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide inhibits OATP1B1, which can raise eluxadoline exposure. Increased eluxadoline levels may cause more adverse effects, such as constipation, pancreatitis and sphincter of Oddi spasm.
How serious is the interaction between Eluxadoline and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced eluxadoline dose of 75 mg twice daily recommended with OATP1B1 inhibitors. Monitor for abdominal pain and constipation.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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