Drug interactions
Eluxadoline + Glimepiride-pioglitazone
Severity: Minor
Eluxadoline and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and pioglitazone is not an established inhibitor of this transporter. A meaningful interaction is not well supported.
What this interaction means in plain words
Eluxadoline and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible weak OATP1B1 inhibition, not clearly established.
What to do
No dose change is needed. Monitor for gastrointestinal adverse effects of eluxadoline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Eluxadoline and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline is an OATP1B1 substrate, and pioglitazone is not an established inhibitor of this transporter. A meaningful interaction is not well supported.
How serious is the interaction between Eluxadoline and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for gastrointestinal adverse effects of eluxadoline.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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