Drug interactions
Eluxadoline + Isoniazid
Severity: Minor
Eluxadoline and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19 in vitro, which could raise eluxadoline exposure. Eluxadoline metabolism is incompletely characterized, and the effect of isoniazid has not been shown to be clinically significant.
What this interaction means in plain words
Eluxadoline and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible inhibition of CYP2C19 by isoniazid reducing eluxadoline clearance.
What to do
No dose adjustment is needed. Monitor for constipation, nausea, abdominal pain and signs of pancreatitis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Isoniazid?
MediHelp rates the interaction as minor. Eluxadoline and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits CYP2C19 in vitro, which could raise eluxadoline exposure. Eluxadoline metabolism is incompletely characterized, and the effect of isoniazid has not been shown to be clinically significant.
How serious is the interaction between Eluxadoline and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for constipation, nausea, abdominal pain and signs of pancreatitis.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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