Drug interactions
Eluxadoline + Methotrexate
Severity: Moderate
Eluxadoline and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits breast cancer resistance protein (BCRP) and may raise systemic exposure to methotrexate, which is a BCRP substrate. Higher methotrexate levels could increase myelosuppression, mucositis and hepatic or renal toxicity, particularly with higher methotrexate doses.
What this interaction means in plain words
Eluxadoline and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
Why it happens
Eluxadoline inhibits BCRP-mediated efflux, which reduces methotrexate elimination and increases its exposure.
What to do
Monitor complete blood count, renal and liver function and signs of methotrexate toxicity when starting eluxadoline. Reduce the methotrexate dose if toxicity appears, especially with high-dose regimens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Methotrexate?
MediHelp rates the interaction as moderate. Eluxadoline and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline inhibits breast cancer resistance protein (BCRP) and may raise systemic exposure to methotrexate, which is a BCRP substrate. Higher methotrexate levels could increase myelosuppression, mucositis and hepatic or renal toxicity, particularly with higher methotrexate doses.
How serious is the interaction between Eluxadoline and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count, renal and liver function and signs of methotrexate toxicity when starting eluxadoline. Reduce the methotrexate dose if toxicity appears, especially with high-dose regimens.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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