Drug interactions
Eluxadoline + Pimozide
Severity: Moderate
Eluxadoline and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may modestly raise exposure of some CYP3A substrates. Because pimozide has a narrow therapeutic index and causes dose-related QT prolongation, even small increases in concentration may be relevant.
What this interaction means in plain words
Eluxadoline and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Eluxadoline may weakly inhibit CYP3A4, reducing pimozide metabolism.
What to do
Monitor ECG/QTc and for pimozide adverse effects when starting eluxadoline. Reduce the pimozide dose if QTc prolongs or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Pimozide?
MediHelp rates the interaction as moderate. Eluxadoline and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline may modestly raise exposure of some CYP3A substrates. Because pimozide has a narrow therapeutic index and causes dose-related QT prolongation, even small increases in concentration may be relevant.
How serious is the interaction between Eluxadoline and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and for pimozide adverse effects when starting eluxadoline. Reduce the pimozide dose if QTc prolongs or toxicity appears.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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