Drug interactions
Eluxadoline + Remifentanil
Severity: Moderate
Eluxadoline and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS, and opioids can cause constipation. Combined use raises the risk of severe constipation and related complications such as ileus.
What this interaction means in plain words
Eluxadoline and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive opioid-receptor-mediated reduction in gastrointestinal motility.
What to do
Short perioperative remifentanil use is usually manageable, but monitor bowel function and stop eluxadoline if severe constipation develops. Avoid prolonged opioid use with eluxadoline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Remifentanil?
MediHelp rates the interaction as moderate. Eluxadoline and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS, and opioids can cause constipation. Combined use raises the risk of severe constipation and related complications such as ileus.
How serious is the interaction between Eluxadoline and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short perioperative remifentanil use is usually manageable, but monitor bowel function and stop eluxadoline if severe constipation develops. Avoid prolonged opioid use with eluxadoline.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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