Drug interactions
Eluxadoline + Triprolidine
Severity: Moderate
Eluxadoline and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline can cause constipation and, rarely, pancreatitis and sphincter of Oddi spasm. Triprolidine has anticholinergic effects that slow gut motility, which may add to the risk of constipation.
What this interaction means in plain words
Eluxadoline and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Triprolidine belongs to Respiratory.
Why it happens
Additive reduction of gastrointestinal motility from opioid receptor agonism and anticholinergic activity.
What to do
Monitor for constipation and stop eluxadoline if severe constipation develops. Consider a non-sedating antihistamine without anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Triprolidine?
MediHelp rates the interaction as moderate. Eluxadoline and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline can cause constipation and, rarely, pancreatitis and sphincter of Oddi spasm. Triprolidine has anticholinergic effects that slow gut motility, which may add to the risk of constipation.
How serious is the interaction between Eluxadoline and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation and stop eluxadoline if severe constipation develops. Consider a non-sedating antihistamine without anticholinergic effects.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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