Drug interactions
Elvitegravir + Eslicarbazepine
Severity: Major
Elvitegravir and Eslicarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is boosted by cobicistat and depends on CYP3A for clearance. Eslicarbazepine may lower concentrations of elvitegravir and the booster, risking virologic failure and resistance.
What this interaction means in plain words
Elvitegravir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction by eslicarbazepine increases metabolism of elvitegravir and cobicistat.
What to do
Use a non-inducing anticonvulsant or alternative antiretroviral regimen. If unavoidable, monitor HIV viral load closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Elvitegravir with Eslicarbazepine?
MediHelp rates the interaction as major. Elvitegravir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elvitegravir is boosted by cobicistat and depends on CYP3A for clearance. Eslicarbazepine may lower concentrations of elvitegravir and the booster, risking virologic failure and resistance.
How serious is the interaction between Elvitegravir and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant or alternative antiretroviral regimen. If unavoidable, monitor HIV viral load closely.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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