Drug interactions
Elvitegravir + Itraconazole
Severity: Moderate
Elvitegravir and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is given with cobicistat, a strong CYP3A inhibitor, which raises itraconazole concentrations. Itraconazole may also raise elvitegravir and cobicistat exposure to a modest degree.
What this interaction means in plain words
Elvitegravir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of itraconazole by cobicistat, with possible reciprocal CYP3A4 inhibition.
What to do
Limit itraconazole to no more than 200 mg/day when used with cobicistat-boosted elvitegravir. Monitor for itraconazole adverse effects and consider drug level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Elvitegravir with Itraconazole?
MediHelp rates the interaction as moderate. Elvitegravir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elvitegravir is given with cobicistat, a strong CYP3A inhibitor, which raises itraconazole concentrations. Itraconazole may also raise elvitegravir and cobicistat exposure to a modest degree.
How serious is the interaction between Elvitegravir and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit itraconazole to no more than 200 mg/day when used with cobicistat-boosted elvitegravir. Monitor for itraconazole adverse effects and consider drug level monitoring.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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