Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Gentamicin
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is renally eliminated and can cause proximal tubular injury, and cobicistat raises serum creatinine by inhibiting tubular secretion. Gentamicin is itself nephrotoxic and ototoxic, so combined use raises the risk of acute kidney injury and aminoglycoside accumulation.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from tenofovir tubular toxicity and aminoglycoside accumulation in proximal tubular cells, with reduced aminoglycoside clearance if renal function falls.
What to do
Avoid concurrent use where possible, or monitor serum creatinine, phosphate and urine protein frequently and measure gentamicin levels. Stop or change therapy if renal function worsens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Gentamicin?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir disoproxil is renally eliminated and can cause proximal tubular injury, and cobicistat raises serum creatinine by inhibiting tubular secretion. Gentamicin is itself nephrotoxic and ototoxic, so combined use raises the risk of acute kidney injury and aminoglycoside accumulation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or monitor serum creatinine, phosphate and urine protein frequently and measure gentamicin levels. Stop or change therapy if renal function worsens.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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