Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Haloperidol
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits both CYP3A4 and CYP2D6, the main enzymes clearing haloperidol, so haloperidol levels may rise. This can increase sedation, extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4 and CYP2D6, decreasing haloperidol metabolism.
What to do
Start haloperidol at a lower dose and titrate by response. Monitor the ECG and watch for extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Haloperidol?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits both CYP3A4 and CYP2D6, the main enzymes clearing haloperidol, so haloperidol levels may rise. This can increase sedation, extrapyramidal effects and QT prolongation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start haloperidol at a lower dose and titrate by response. Monitor the ECG and watch for extrapyramidal symptoms.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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