Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Losartan
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may modestly alter losartan metabolism, while elvitegravir may weakly induce CYP2C9, which forms losartan's active metabolite. Net effects on losartan exposure and effect are unpredictable and usually modest.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4 and elvitegravir may induce CYP2C9, both involved in losartan biotransformation.
What to do
Monitor blood pressure and adjust the losartan dose to response. Watch for hypotension or reduced antihypertensive effect after starting or stopping the regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Losartan?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and may modestly alter losartan metabolism, while elvitegravir may weakly induce CYP2C9, which forms losartan's active metabolite. Net effects on losartan exposure and effect are unpredictable and usually modest.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the losartan dose to response. Watch for hypotension or reduced antihypertensive effect after starting or stopping the regimen.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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