Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mefenamic acid
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mefenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney, and NSAIDs can reduce renal perfusion, which may increase tenofovir exposure and the risk of kidney injury. Cobicistat also raises serum creatinine by inhibiting tubular secretion, which can complicate assessment of renal function.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion and competition for renal elimination, adding to tenofovir tubular toxicity risk.
What to do
Avoid chronic or high-dose NSAID use and choose an alternative analgesic such as paracetamol; if unavoidable, monitor creatinine clearance and urinary markers regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mefenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Mefenamic acid?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is eliminated by the kidney, and NSAIDs can reduce renal perfusion, which may increase tenofovir exposure and the risk of kidney injury. Cobicistat also raises serum creatinine by inhibiting tubular secretion, which can complicate assessment of renal function.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic or high-dose NSAID use and choose an alternative analgesic such as paracetamol; if unavoidable, monitor creatinine clearance and urinary markers regularly.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
