Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Nabumetone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney and can cause tubular toxicity, and NSAIDs can reduce renal perfusion. Concurrent use, especially with high or repeated NSAID doses, may increase the risk of acute kidney injury.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity: NSAID-induced reduction in renal prostaglandin-dependent perfusion superimposed on tenofovir proximal tubular toxicity; cobicistat also raises serum creatinine.
What to do
Prefer non-NSAID analgesics such as paracetamol. If an NSAID is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Nabumetone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by the kidney and can cause tubular toxicity, and NSAIDs can reduce renal perfusion. Concurrent use, especially with high or repeated NSAID doses, may increase the risk of acute kidney injury.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics such as paracetamol. If an NSAID is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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