Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Oxaliplatin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF and cobicistat can affect renal tubular function and serum creatinine, and oxaliplatin may add renal stress. Combined use may worsen kidney function and raise renal drug exposure.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and reduced renal clearance of renally eliminated drugs.
What to do
Monitor serum creatinine, phosphate and urine protein during oxaliplatin therapy. Consider an alternative antiretroviral regimen if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Oxaliplatin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF and cobicistat can affect renal tubular function and serum creatinine, and oxaliplatin may add renal stress. Combined use may worsen kidney function and raise renal drug exposure.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urine protein during oxaliplatin therapy. Consider an alternative antiretroviral regimen if renal function deteriorates.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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