Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Perphenazine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component inhibits CYP2D6 and CYP3A4 and can increase perphenazine concentrations. This may intensify sedation, extrapyramidal effects and QT risk.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6-mediated metabolism of perphenazine.
What to do
Consider reducing the perphenazine dose and monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Perphenazine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cobicistat component inhibits CYP2D6 and CYP3A4 and can increase perphenazine concentrations. This may intensify sedation, extrapyramidal effects and QT risk.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the perphenazine dose and monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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