Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Saxagliptin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and raises saxagliptin exposure. This can increase saxagliptin adverse effects.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated saxagliptin metabolism.
What to do
Limit saxagliptin to 2.5 mg once daily and monitor glycemic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Saxagliptin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and raises saxagliptin exposure. This can increase saxagliptin adverse effects.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily and monitor glycemic response.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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