Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Solifenacin
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and increases solifenacin exposure. This can enhance anticholinergic effects and QT prolongation risk.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4, decreasing solifenacin clearance.
What to do
Limit solifenacin to 5 mg daily and monitor for anticholinergic effects and QT-related symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Solifenacin?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and increases solifenacin exposure. This can enhance anticholinergic effects and QT prolongation risk.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily and monitor for anticholinergic effects and QT-related symptoms.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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