Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Torsemide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Torsemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9 while cobicistat inhibits CYP enzymes, so the net effect on torsemide exposure is uncertain. Diuretic response may change, and tenofovir adds renal considerations in patients on loop diuretics.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CYP2C9 induction by elvitegravir and weak inhibition by cobicistat alter torsemide metabolism to an unclear net effect.
What to do
Monitor diuretic response, fluid status and renal function, and adjust the torsemide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Torsemide
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Torsemide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may induce CYP2C9 while cobicistat inhibits CYP enzymes, so the net effect on torsemide exposure is uncertain. Diuretic response may change, and tenofovir adds renal considerations in patients on loop diuretics.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Torsemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, fluid status and renal function, and adjust the torsemide dose as needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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