Drug interactions
Empagliflozin-linagliptin + Ethacrynic acid
Severity: Moderate
Empagliflozin-linagliptin and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and natriuresis, and a loop diuretic such as ethacrynic acid adds to this effect. Together they can cause volume depletion, hypotension, dizziness, electrolyte disturbance and acute kidney injury, especially in older or renally impaired patients.
What this interaction means in plain words
Empagliflozin-linagliptin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic diuretic and natriuretic effects from SGLT2 inhibition and loop diuretic action.
What to do
Assess volume status, blood pressure, renal function and electrolytes when starting or adjusting either drug. Consider reducing the diuretic dose if signs of volume depletion occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-linagliptin and Ethacrynic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-linagliptin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Empagliflozin-linagliptin with Ethacrynic acid?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and natriuresis, and a loop diuretic such as ethacrynic acid adds to this effect. Together they can cause volume depletion, hypotension, dizziness, electrolyte disturbance and acute kidney injury, especially in older or renally impaired patients.
How serious is the interaction between Empagliflozin-linagliptin and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status, blood pressure, renal function and electrolytes when starting or adjusting either drug. Consider reducing the diuretic dose if signs of volume depletion occur.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
