Drug interactions
Empagliflozin-linagliptin + Etravirine
Severity: Moderate
Empagliflozin-linagliptin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering effect. Linagliptin is only partly metabolized by CYP3A4, so the effect is likely modest.
What this interaction means in plain words
Empagliflozin-linagliptin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 and possibly P-glycoprotein by etravirine increases linagliptin clearance.
What to do
Monitor blood glucose and HbA1c after starting etravirine and add or adjust other antidiabetic therapy if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Etravirine?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering effect. Linagliptin is only partly metabolized by CYP3A4, so the effect is likely modest.
How serious is the interaction between Empagliflozin-linagliptin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting etravirine and add or adjust other antidiabetic therapy if control is inadequate.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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