Drug interactions
Empagliflozin-linagliptin + Furosemide
Severity: Moderate
Empagliflozin-linagliptin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin and furosemide both increase urinary fluid and sodium loss, which can lead to dehydration, hypotension and kidney function decline.
What this interaction means in plain words
Empagliflozin-linagliptin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor volume status, blood pressure, electrolytes and creatinine, especially in the early weeks. Consider reducing furosemide dose if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Furosemide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin and furosemide both increase urinary fluid and sodium loss, which can lead to dehydration, hypotension and kidney function decline.
How serious is the interaction between Empagliflozin-linagliptin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure, electrolytes and creatinine, especially in the early weeks. Consider reducing furosemide dose if volume depleted.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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