Drug interactions
Empagliflozin-linagliptin + Itraconazole
Severity: Minor
Empagliflozin-linagliptin and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and may raise linagliptin exposure modestly. Linagliptin has a wide safety margin and a mainly non-metabolic elimination route, so the clinical effect is usually small.
What this interaction means in plain words
Empagliflozin-linagliptin and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces linagliptin clearance.
What to do
No dose adjustment is generally needed. Monitor blood glucose as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Empagliflozin-linagliptin with Itraconazole?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and may raise linagliptin exposure modestly. Linagliptin has a wide safety margin and a mainly non-metabolic elimination route, so the clinical effect is usually small.
How serious is the interaction between Empagliflozin-linagliptin and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor blood glucose as part of routine care.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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