Drug interactions
Empagliflozin-linagliptin + Lasmiditan
Severity: Minor
Empagliflozin-linagliptin and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein, which may raise linagliptin exposure. Linagliptin has a wide safety margin, so the increase is unlikely to cause serious harm.
What this interaction means in plain words
Empagliflozin-linagliptin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, which may increase absorption of linagliptin, a P-gp substrate.
What to do
No dose change is normally needed; monitor glycemic control and watch for gastrointestinal or hypersensitivity effects of linagliptin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Empagliflozin-linagliptin with Lasmiditan?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein, which may raise linagliptin exposure. Linagliptin has a wide safety margin, so the increase is unlikely to cause serious harm.
How serious is the interaction between Empagliflozin-linagliptin and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor glycemic control and watch for gastrointestinal or hypersensitivity effects of linagliptin.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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