Drug interactions
Empagliflozin-linagliptin + Lonafarnib
Severity: Minor
Empagliflozin-linagliptin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-gp inhibitor and may modestly increase linagliptin exposure. Linagliptin is well tolerated at higher exposures, so clinical significance is likely small.
What this interaction means in plain words
Empagliflozin-linagliptin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak P-gp inhibition by lonafarnib decreases linagliptin efflux.
What to do
No dose adjustment is usually needed. Watch for hypoglycemia if combined with insulin or a sulfonylurea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Empagliflozin-linagliptin with Lonafarnib?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-gp inhibitor and may modestly increase linagliptin exposure. Linagliptin is well tolerated at higher exposures, so clinical significance is likely small.
How serious is the interaction between Empagliflozin-linagliptin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for hypoglycemia if combined with insulin or a sulfonylurea.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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