Drug interactions
Empagliflozin-metformin + Famotidine
Severity: Minor
Empagliflozin-metformin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may slightly raise metformin exposure by reducing its renal clearance. The effect is usually small and of limited clinical importance.
What this interaction means in plain words
Empagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Possible competition for renal tubular secretion via cationic transporters.
What to do
No routine adjustment is needed. Monitor renal function and metformin tolerability in patients with kidney impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Empagliflozin-metformin with Famotidine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may slightly raise metformin exposure by reducing its renal clearance. The effect is usually small and of limited clinical importance.
How serious is the interaction between Empagliflozin-metformin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and metformin tolerability in patients with kidney impairment.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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