Drug interactions
Empagliflozin-metformin + Fluoxetine
Severity: Minor
Empagliflozin-metformin and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can improve insulin sensitivity and lower blood glucose in some diabetic patients. This may increase the glucose-lowering effect of empagliflozin-metformin, with a small risk of hypoglycemia.
What this interaction means in plain words
Empagliflozin-metformin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Fluoxetine belongs to Central Nervous System.
Why it happens
Serotonergic effects may enhance insulin sensitivity, producing an additive hypoglycemic effect; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping fluoxetine. Reduce antidiabetic doses only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Fluoxetine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine can improve insulin sensitivity and lower blood glucose in some diabetic patients. This may increase the glucose-lowering effect of empagliflozin-metformin, with a small risk of hypoglycemia.
How serious is the interaction between Empagliflozin-metformin and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluoxetine. Reduce antidiabetic doses only if hypoglycemia occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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