Drug interactions
Empagliflozin-metformin + Levofloxacin
Severity: Moderate
Empagliflozin-metformin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in diabetic patients on glucose-lowering drugs. Severe hypoglycemia has been reported.
What this interaction means in plain words
Empagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, altering insulin release and causing dysglycemia.
What to do
Monitor blood glucose closely during the antibiotic course and counsel the patient on hypoglycemia symptoms. Switch to a non-fluoroquinolone antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Empagliflozin-metformin with Levofloxacin?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in diabetic patients on glucose-lowering drugs. Severe hypoglycemia has been reported.
How serious is the interaction between Empagliflozin-metformin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and counsel the patient on hypoglycemia symptoms. Switch to a non-fluoroquinolone antibiotic if glucose becomes unstable.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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