Drug interactions
Empagliflozin-metformin + Linezolid
Severity: Moderate
Empagliflozin-metformin and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in diabetic patients receiving insulin or oral antidiabetic agents. It may also cause lactic acidosis, which overlaps with the metformin-associated lactic acidosis risk.
What this interaction means in plain words
Empagliflozin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Linezolid can impair mitochondrial function, causing lactate accumulation, and it may enhance glucose lowering through an incompletely defined mechanism.
What to do
Monitor blood glucose during linezolid therapy and counsel the patient on hypoglycemia symptoms. Evaluate promptly for lactic acidosis if nausea, vomiting, malaise, or tachypnea develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Linezolid?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in diabetic patients receiving insulin or oral antidiabetic agents. It may also cause lactic acidosis, which overlaps with the metformin-associated lactic acidosis risk.
How serious is the interaction between Empagliflozin-metformin and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and counsel the patient on hypoglycemia symptoms. Evaluate promptly for lactic acidosis if nausea, vomiting, malaise, or tachypnea develop.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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