Drug interactions
Empagliflozin-metformin + Nizatidine
Severity: Minor
Empagliflozin-metformin and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine can reduce the renal tubular secretion of metformin, which may raise metformin exposure. Higher metformin levels could increase the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced kidney function.
What this interaction means in plain words
Empagliflozin-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) reduces metformin renal clearance.
What to do
Monitor glycemic control and renal function, and reduce the metformin dose if tolerability problems appear. Take extra care in patients with impaired renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Empagliflozin-metformin with Nizatidine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine can reduce the renal tubular secretion of metformin, which may raise metformin exposure. Higher metformin levels could increase the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced kidney function.
How serious is the interaction between Empagliflozin-metformin and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and reduce the metformin dose if tolerability problems appear. Take extra care in patients with impaired renal function.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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