Drug interactions
Empagliflozin-metformin + Quetiapine
Severity: Moderate
Empagliflozin-metformin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is associated with weight gain, insulin resistance and hyperglycemia, which can undermine glycemic control in patients with diabetes. Rarely it contributes to ketoacidosis, which is also a concern with SGLT2 inhibitors.
What this interaction means in plain words
Empagliflozin-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and weight gain oppose the glucose-lowering effect of the antidiabetic drugs.
What to do
Check fasting glucose and HbA1c at baseline and periodically, and intensify antidiabetic therapy if needed. Educate the patient on symptoms of ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Empagliflozin-metformin with Quetiapine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is associated with weight gain, insulin resistance and hyperglycemia, which can undermine glycemic control in patients with diabetes. Rarely it contributes to ketoacidosis, which is also a concern with SGLT2 inhibitors.
How serious is the interaction between Empagliflozin-metformin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically, and intensify antidiabetic therapy if needed. Educate the patient on symptoms of ketoacidosis.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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