Drug interactions
Empagliflozin-metformin + Quinidine
Severity: Moderate
Empagliflozin-metformin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine competes with metformin for renal tubular secretion and can raise metformin exposure. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Empagliflozin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits renal organic cation transporters (OCT2 and MATE), reducing metformin tubular secretion.
What to do
Monitor glucose and renal function and consider reducing the metformin dose if adverse effects appear. Avoid the combination in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Quinidine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine competes with metformin for renal tubular secretion and can raise metformin exposure. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
How serious is the interaction between Empagliflozin-metformin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function and consider reducing the metformin dose if adverse effects appear. Avoid the combination in patients with significant renal impairment.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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