Drug interactions
Empagliflozin-metformin + Repaglinide
Severity: Moderate
Empagliflozin-metformin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an SGLT2 inhibitor to an insulin secretagogue such as repaglinide can increase the risk of hypoglycemia. The glucose-lowering effects of the two agents are additive.
What this interaction means in plain words
Empagliflozin-metformin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering: insulin secretion stimulated by repaglinide plus glycosuria from empagliflozin.
What to do
Consider lowering the repaglinide dose when starting empagliflozin-metformin, and monitor blood glucose. Counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Empagliflozin-metformin with Repaglinide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an SGLT2 inhibitor to an insulin secretagogue such as repaglinide can increase the risk of hypoglycemia. The glucose-lowering effects of the two agents are additive.
How serious is the interaction between Empagliflozin-metformin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the repaglinide dose when starting empagliflozin-metformin, and monitor blood glucose. Counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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