Drug interactions
Metformin-pioglitazone + Risdiplam
Severity: Moderate
Metformin-pioglitazone and Risdiplam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risdiplam inhibits the renal MATE transporters that clear metformin, so metformin exposure can rise. Higher metformin levels increase the risk of gastrointestinal effects and lactic acidosis.
What this interaction means in plain words
Metformin-pioglitazone and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Risdiplam belongs to Musculoskeletal.
Why it happens
Risdiplam inhibits MATE1 and MATE2-K, reducing renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function and consider lowering the metformin dose if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Risdiplam
- Alogliptin-metformin + Risdiplam Moderate
- Canagliflozin-metformin + Risdiplam Moderate
- Dapagliflozin-metformin + Risdiplam Moderate
- Empagliflozin-metformin + Risdiplam Moderate
- Glyburide-metformin + Risdiplam Moderate
- Linagliptin-metformin + Risdiplam Moderate
Frequently asked questions
Can I take Metformin-pioglitazone with Risdiplam?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risdiplam inhibits the renal MATE transporters that clear metformin, so metformin exposure can rise. Higher metformin levels increase the risk of gastrointestinal effects and lactic acidosis.
How serious is the interaction between Metformin-pioglitazone and Risdiplam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function and consider lowering the metformin dose if the combination is needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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