Drug interactions
Empagliflozin-metformin + Thioridazine
Severity: Moderate
Empagliflozin-metformin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine, a phenothiazine, may cause hyperglycemia and impaired glucose tolerance, reducing the effect of metformin and empagliflozin. Glucose may fall again when it is withdrawn.
What this interaction means in plain words
Empagliflozin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Phenothiazine effects on insulin secretion and insulin resistance oppose the antidiabetic effect.
What to do
Monitor blood glucose when starting, changing or stopping thioridazine and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Thioridazine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine, a phenothiazine, may cause hyperglycemia and impaired glucose tolerance, reducing the effect of metformin and empagliflozin. Glucose may fall again when it is withdrawn.
How serious is the interaction between Empagliflozin-metformin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping thioridazine and adjust antidiabetic doses accordingly.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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