Drug interactions
Emtricitabine + Flurbiprofen
Severity: Moderate
Emtricitabine and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion. NSAIDs can reduce renal function and compete for tubular secretion, which may raise emtricitabine levels, particularly with high or repeated NSAID doses and pre-existing renal impairment.
What this interaction means in plain words
Emtricitabine and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal function and possible competition for tubular secretion reduces emtricitabine clearance.
What to do
Monitor renal function in patients taking emtricitabine, especially with tenofovir-containing regimens, and limit NSAID dose and duration. Consider alternative analgesics such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Flurbiprofen?
MediHelp rates the interaction as moderate. Emtricitabine and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion. NSAIDs can reduce renal function and compete for tubular secretion, which may raise emtricitabine levels, particularly with high or repeated NSAID doses and pre-existing renal impairment.
How serious is the interaction between Emtricitabine and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients taking emtricitabine, especially with tenofovir-containing regimens, and limit NSAID dose and duration. Consider alternative analgesics such as paracetamol.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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