Drug interactions
Emtricitabine + Naproxen
Severity: Moderate
Emtricitabine and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose or multiple-dose NSAIDs may reduce emtricitabine elimination and add to renal stress. Emtricitabine accumulation matters mainly in patients with reduced kidney function.
What this interaction means in plain words
Emtricitabine and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Naproxen belongs to Musculoskeletal.
Why it happens
NSAIDs reduce renal perfusion and may compete for tubular secretion, lowering emtricitabine clearance.
What to do
Monitor renal function and consider alternatives to regular NSAID use. Adjust the emtricitabine dose if creatinine clearance declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Naproxen?
MediHelp rates the interaction as moderate. Emtricitabine and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose or multiple-dose NSAIDs may reduce emtricitabine elimination and add to renal stress. Emtricitabine accumulation matters mainly in patients with reduced kidney function.
How serious is the interaction between Emtricitabine and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and consider alternatives to regular NSAID use. Adjust the emtricitabine dose if creatinine clearance declines.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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