Drug interactions
Emtricitabine + Tolmetin
Severity: Moderate
Emtricitabine and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are eliminated by the kidney, and NSAIDs may reduce renal function, potentially raising emtricitabine exposure. The concern is greatest with high or repeated NSAID doses and in renal impairment.
What this interaction means in plain words
Emtricitabine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal function and possible competition for tubular secretion reduces emtricitabine clearance.
What to do
Prefer a non-NSAID analgesic during prolonged use. Monitor renal function and adjust the emtricitabine dose if creatinine clearance declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Tolmetin?
MediHelp rates the interaction as moderate. Emtricitabine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are eliminated by the kidney, and NSAIDs may reduce renal function, potentially raising emtricitabine exposure. The concern is greatest with high or repeated NSAID doses and in renal impairment.
How serious is the interaction between Emtricitabine and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic during prolonged use. Monitor renal function and adjust the emtricitabine dose if creatinine clearance declines.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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