Drug interactions
Enalapril + Ethacrynic acid
Severity: Moderate
Enalapril and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that causes volume depletion, which can lead to marked first-dose hypotension and acute kidney injury when enalapril is started or doses raised.
What this interaction means in plain words
Enalapril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion makes blood pressure and glomerular filtration dependent on angiotensin II, which enalapril blocks.
What to do
Consider reducing or holding the diuretic before starting enalapril, begin with a low dose, and check blood pressure, creatinine and potassium within the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Enalapril with Ethacrynic acid?
MediHelp rates the interaction as moderate. Enalapril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that causes volume depletion, which can lead to marked first-dose hypotension and acute kidney injury when enalapril is started or doses raised.
How serious is the interaction between Enalapril and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or holding the diuretic before starting enalapril, begin with a low dose, and check blood pressure, creatinine and potassium within the first weeks.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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