Drug interactions
Enalapril + Insulin glargine
Severity: Moderate
Enalapril and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity, so insulin glargine can lower glucose more than expected. Hypoglycemia is the main concern, especially after the ACE inhibitor is introduced.
What this interaction means in plain words
Enalapril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
ACE inhibition increases bradykinin and improves peripheral insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Increase glucose monitoring when enalapril is started or adjusted. Reduce the insulin glargine dose if hypoglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Enalapril with Insulin glargine?
MediHelp rates the interaction as moderate. Enalapril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity, so insulin glargine can lower glucose more than expected. Hypoglycemia is the main concern, especially after the ACE inhibitor is introduced.
How serious is the interaction between Enalapril and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when enalapril is started or adjusted. Reduce the insulin glargine dose if hypoglycemia appears.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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