Drug interactions
Enalapril + Letermovir
Severity: Minor
Enalapril and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits hepatic OATP1B1/3 transporters and may increase concentrations of substrates such as enalapril. Higher exposure could increase hypotension or effects on renal function and potassium.
What this interaction means in plain words
Enalapril and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits OATP1B1/3 hepatic uptake, potentially increasing enalapril exposure.
What to do
No dose change is usually needed; monitor blood pressure, renal function and potassium during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Enalapril with Letermovir?
MediHelp rates the interaction as minor. Enalapril and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits hepatic OATP1B1/3 transporters and may increase concentrations of substrates such as enalapril. Higher exposure could increase hypotension or effects on renal function and potassium.
How serious is the interaction between Enalapril and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure, renal function and potassium during coadministration.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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