Drug interactions
Enalapril + Liraglutide
Severity: Minor
Enalapril and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may modestly enhance glucose lowering when given with GLP-1 agonists. The clinical effect is small and hypoglycemia is uncommon unless other glucose-lowering drugs such as insulin or sulfonylureas are also used.
What this interaction means in plain words
Enalapril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
The mechanism is not well established; improved insulin sensitivity from ACE inhibition may contribute to additive glucose lowering.
What to do
Monitor glycemic control after enalapril is started, particularly in patients also taking insulin or a sulfonylurea. Reduce the dose of those agents if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Enalapril with Liraglutide?
MediHelp rates the interaction as minor. Enalapril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may modestly enhance glucose lowering when given with GLP-1 agonists. The clinical effect is small and hypoglycemia is uncommon unless other glucose-lowering drugs such as insulin or sulfonylureas are also used.
How serious is the interaction between Enalapril and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control after enalapril is started, particularly in patients also taking insulin or a sulfonylurea. Reduce the dose of those agents if hypoglycemia occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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