Drug interactions
Enalapril + Lornoxicam
Severity: Moderate
Enalapril and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam can attenuate the blood pressure lowering effect of enalapril. In at-risk patients the combination increases the risk of renal impairment and hyperkalemia.
What this interaction means in plain words
Enalapril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium retention and decreased renal perfusion, opposing ACE inhibition.
What to do
Monitor blood pressure, creatinine and potassium, particularly in elderly or volume-depleted patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Enalapril with Lornoxicam?
MediHelp rates the interaction as moderate. Enalapril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam can attenuate the blood pressure lowering effect of enalapril. In at-risk patients the combination increases the risk of renal impairment and hyperkalemia.
How serious is the interaction between Enalapril and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, particularly in elderly or volume-depleted patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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