Drug interactions
Enalapril + Lurasidone
Severity: Moderate
Enalapril and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Combined with enalapril, blood pressure may fall further, causing dizziness or syncope, especially at initiation or dose increases.
What this interaction means in plain words
Enalapril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism by lurasidone and ACE inhibition by enalapril.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Enalapril with Lurasidone?
MediHelp rates the interaction as moderate. Enalapril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Combined with enalapril, blood pressure may fall further, causing dizziness or syncope, especially at initiation or dose increases.
How serious is the interaction between Enalapril and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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