Drug interactions
Enalapril + Trofinetide
Severity: Moderate
Enalapril and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. The effect on enalapril is not well characterized and is probably limited.
What this interaction means in plain words
Enalapril and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transporters by trofinetide may alter enalapril disposition.
What to do
Monitor blood pressure and renal function when trofinetide is started or stopped. Adjust the enalapril dose if hypotension or reduced efficacy occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril and Trofinetide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Enalapril with Trofinetide?
MediHelp rates the interaction as moderate. Enalapril and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. The effect on enalapril is not well characterized and is probably limited.
How serious is the interaction between Enalapril and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when trofinetide is started or stopped. Adjust the enalapril dose if hypotension or reduced efficacy occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
