Drug interactions
Enalapril-hydrochlorothiazide + Enoxaparin
Severity: Moderate
Enalapril-hydrochlorothiazide and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone production and cause hyperkalemia, and the effect is additive with ACE inhibitors. The risk is higher in renal impairment, diabetes and prolonged therapy.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to ACE inhibitor reduction of aldosterone.
What to do
Monitor serum potassium and renal function, especially if enoxaparin is used for more than a few days or in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Enoxaparin?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone production and cause hyperkalemia, and the effect is additive with ACE inhibitors. The risk is higher in renal impairment, diabetes and prolonged therapy.
How serious is the interaction between Enalapril-hydrochlorothiazide and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially if enoxaparin is used for more than a few days or in high-risk patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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